Fantastic stuff, as usual, Brian. The First Link Priority Rule is always one that causes me great angst. I often get torn between search engines and usability when it comes to the main navigation bar. And, I’ve never known what the heck to do about the “Home” link. You can hardly target your keywords with that one without it being anything but awkward.
Lastly, it's important to remember that paralysis by over-thinking is a real issue some struggle with. There's no pill for it (yet). Predicting perfection is a fool's errand. Get as close as you can within a reasonable timeframe, and prepare for future iteration. If you're traveling through your plan and determine a soft spot at any time, simply pivot. It's many hours of upfront work to get your strategy built, but it's not too hard to tweak as you go.